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Aflur

Pack : 5ml pack
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DESCRIPATION:

Aflur- Eye Drops (Flurbiprofen eye drops) are used to keep the pupils of the eye from getting smaller (miosis) during an eye surgery. This medicine is a topical nonsteroidal anti-inflammatory drug (NSAID).

COMPOSITION:

Label Claim: Each mL Contains :

  • Flurbiprofen Sodium IP……… 0.3 mg
  • Thimerosal IP……………………0.05 mg
  • Aqueous Buffered Vehicle..……….q.s.

PACKAGING

Primary packing - 5ml White Poly bottles White caps &Nozzles.

Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.

AVAILABILITY

5ml of solution in White poly bottles with white caps & nozzles in properly sealed.

SHELF LIFE:

24 months from the date of manufacturing.

STORAGE:

Keep in a cool & dark place. Below 25ºC.Do not allow to Freeze.

CLINICAL PHARMACOLOGY:

Flurbiprofen sodium is one of a series of phenylalkanoic acids that have shown analgesic, antipyretic, and anti-inflammatory activity in animal inflammatory diseases. Its mechanism of action is believed to be through inhibition of the cyclo-oxygenase enzyme that is essential in the biosynthesis of prostaglandins.

Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed on animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilatation, increased vascular permeability, leukocytosis, and increased intraocular pressure.

Prostaglandins also appear to play a role in the miotic response produced during ocular surgery by constricting the iris sphincter independently of cholinergic mechanisms. In clinical studies, Aflur- Eye Drops has been shown to inhibit the miosis induced during the course of cataract surgery.

Results from clinical studies indicate that flurbiprofen sodium has no significant effect upon intraocular pressure.

INDICATIONS AND USAGE:

Aflur- Eye Drops is is indicated for the inhibition of intraoperative miosis.

CONTRAINDICATIONS:

Aflur- Eye Drops is contraindicated in individuals who are hypersensitive to any components of the medication.

WARNINGS:

With some nonsteroidal anti-inflammatory drugs, there exists the potential for increased bleeding time due to interference with thrombocyte aggregation. There have been reports that Aflur- Eye Drops may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery.
There is the potential for cross-sensitivity to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs.

DOSAGE AND ADMINISTRATION:

A total of four (4) drops of Aflur- Eye Drops should be administered by instilling one (1) drop approximately every 1/2 hour beginning 2 hours before surgery.

SUPPLY:

Aflur- Eye Drops is supplied in one White polethylene Bottle packed with printed labelled & cartons And Such 25 Carton Packed in a Shrink Sleeves & corrugated box.

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