ANTI-ALLERGIC
ALLER-NIL
Pack : 5ml Pack
DESCRIPTION:
Allernil- Eye Drops (Cromolyn Sodium Ophthalmic Solution) is an anti-inflammatory medication used to treat allergysymptoms that affect the eyes, such as itching, burning, watering, swelling, redness, or sensitivity to light. Opticrom is available in generic form. Common side effects of Opticrom include burning or stinging of the eye after you use the eye drops, dry or irritated eyes, puffy eyes, or watery eyes.
COMPOSITION:
Label Claim: Each ML Contains :
• Cromolyn Sodium USP...........20 mg
• Benzalkonium Chloride Solution USP......0.1mg
• Aqueous Buffered Vehicle...........q.s.
PACKAGING
Primary packing - 5ml Opaque poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
AVAILABILITY
5ml of solution in White poly bottles with white caps & nozzles in properly sealed.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 30ºC.Do not allow to Freeze.
CLINICAL PHARMACOLOGY:
In vitro and in vivo animal studies have shown that cromolyn sodium inhibits the degranulation of sensitized mast cells which occurs after exposure to specific antigens. Cromolyn sodium acts by inhibiting the release of histamine and SRS-A (slow-reacting substance of anaphylaxis) from the mast cell.
Another activity demonstrated in vitro is the capacity of cromolyn sodium to inhibit the degranulation of non-sensitized rat mast cells by phospholipase A and the subsequent release of chemical mediators. Another study showed that cromolyn sodium did not inhibit the enzymatic activity of released phospholipase A on its specific substrate.
Cromolyn sodium has no intrinsic vasoconstrictor, antihistaminic or anti-inflammatory activity.Cromolyn sodium is poorly absorbed. When multiple doses of cromolyn sodium ophthalmic solution are instilled into normal rabbit eyes, less than 0.07% of the administered dose of cromolyn sodium is absorbed into the systemic circulation (presumably by way of the eye, nasal passages, buccal cavity and gastrointestinal tract). Trace amounts (less than 0.01%) of the cromolyn sodium dose penetrate into the aqueous humor and clearance from this chamber is virtually complete within 24 hours after treatment is stopped.
In normal volunteers, analysis of drug excretion indicates that approximately 0.03% of cromolyn sodium is absorbed following administration to the eye.
INDICATIONS AND USAGE:
Allernil- Eye Drops (Cromolyn Sodium Ophthalmic Solution) is is indicated in the treatment of vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
CONTRAINDICATIONS:
Allernil- Eye Drops (Cromolyn Sodium Ophthalmic Solution) is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or to any of the other ingredients.
WARNINGS :
Allernil- Eye Drops (Cromolyn Sodium Ophthalmic Solution) is for topical use only and not for injection or oral use.
DOSAGE AND ADMINISTRATION:
The dose is 1 or 2 drops in each eye 4 to 6 times a day at regular intervals. One drop contains approximately 1.6 mg cromolyn sodium.
Patients should be advised that the effect of cromolyn sodium ophthalmic solution therapy is dependent upon its administration at regular intervals, as directed.
Symptomatic response to therapy (decreased itching, tearing, redness, and discharge) is usually evident within a few days, but longer treatment for up to six weeks is sometimes required. Once symptomatic improvement has been established, therapy should be continued for as long as needed to sustain improvement.
If required, corticosteroids may be used concomitantly with Allernil- Eye Drops (Cromolyn Sodium Ophthalmic Solution).
SUPPLY:
Allernil- Eye Drops is supplied in one clear polethylene Bottle packed with printed labelled & cartons And Such 25 Carton Packed in a Shrink Sleeves & corrugated box.
ALLERNIL-O
Pack : 5ml Pack
DESCRIPTION:
Allernil-O Eye Drops (Olopatadine Hydrochloride Ophthalmic Solution) is a sterile ophthalmic solution containing olopatadine, a relatively selective H1-receptor antagonist and inhibitor of histamine release from the mast cell for topical administration to the eyes.
COMPOSITION:
Label Claim: Each ML Contains :
Olopatadine Hydrochloride IP
- Equivalent to Olopatadine......... 0.1% w/v
- Benzalkonium Chloride Solution IP.........0.01%w/v
- Sterile aqueous Vehicle..........q.s.Sterile aqueous Vehicle..........q.s.
PACKAGING:
Primary packing - 5ml Opaque poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
AVAILABILITY:
5ml of solution in White poly bottles with white caps & nozzles in properly sealed.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 30ºC.Do not allow to Freeze.
CLINICAL PHARMACOLOGY:
Olopatadine is an inhibitor of the release of histamine from the mast cell and a relatively selective histamine H1-antagonist that inhibits the in vivo and in vitro type 1 immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells. Olopatadine is devoid of effects on alpha-adrenergic, dopamine and muscarinic type 1 and 2 receptors. Following topical ocular administration in man, olopatadine was shown to have low systemic exposure. Two studies in normal volunteers (totaling 24 subjects) dosed bilaterally with olopatadine 0.15% ophthalmic solution once every 12 hours for 2 weeks demonstrated plasma concentrations to be generally below the quantitation limit of the assay (<0.5 ng/mL). Samples in which olopatadine was quantifiable were typically found within 2 hours of dosing and ranged from 0.5 to 1.3 ng/mL. The half-life in plasma was approximately 3 hours, and elimination was predominantly through renal excretion. Approximately 60-70% of the dose was recovered in the urine as parent drug. Two metabolites, the mono-desmethyl and the N-oxide, were detected at low concentrations in the urine.
Results from an environmental study demonstrated that Allernil-O Eye Drops (Olopatadine Hydrochloride Ophthalmic Solution), was effective in the treatment of the signs and symptoms of allergic conjunctivitis when dosed twice daily for up to 6 weeks. Results from conjunctival antigen challenge studies demonstrated that Allernil-O Eye Drops (Olopatadine Hydrochloride Ophthalmic Solution), when subjects were challenged with antigen both initially and up to 8 hours after dosing, was significantly more effective than its vehicle in preventing ocular itching associated with allergic conjunctivitis.
INDICATIONS AND USAGE:
Allernil-O Eye Drops (Olopatadine Hydrochloride Ophthalmic Solution) is indicated for the treatment of the signs and symptoms of allergic conjunctivitis.
CONTRAINDICATIONS:
Allernil-O Eye Drops (Olopatadine Hydrochloride Ophthalmic Solution) is contraindicated in persons with a known hypersensitivity to Olopatadine Hydrochloride or any components of Olopatadine Hydrochloride Ophthalmic Solution.
WARNINGS :
Allernil-O Eye Drops (Olopatadine Hydrochloride Ophthalmic Solution) is for topical use only and not for injection or oral use.
DOSAGE AND ADMINISTRATION:
The recommended dose is one drop in each affected eye two times per day at an interval of 6 to 8 hours.
SUPPLY:
Allernil-O Eye Drops is supplied in one White polethylene Bottle packed with printed labelled & cartons And Such 25 Carton Packed in a Shrink Sleeves & corrugated box.
ANC
Pack : 10ml Pack
DESCRIPTION:
ANC Eye Drops actas an anti allergic, astringent & decongestant. Naphazoline acts as a vasoconstrictor to narrow swollen blood vessels to reduce the redness.
Hydrxtpropylmethyl cellulose acts as lubricant to give relief from dry irritated eyes.
Chlorpheniramine maleate acts as antiallergic gives relief from itching, watering of eyes due to allergy
.Zinc sulphate acts as an astringent that helps clear mucus from the outer surface of the eye often associated with exposure to pollen, dust and smoke.
COMPOSITION:
Label Claim: Each ML Contains :
• Naphazoline Hcl USP .............. 0.56 mg
• Chlorpheniramine Maleate IP............0.1mg
• Zinc Sulphate IP..................1.2 mg
• Hypromellose IP ................2 mg
• Benzalkonium Chloride Solution IP..........0.0001ml (as preservative)
• Sterile Aqueous vehicle............q.s.
PACKAGING
Primary packing - 10ml Opaque poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
AVAILABILITY
10ml of solution in White poly bottles with white caps & nozzles in properly sealed.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 30ºC.Do not allow to Freeze.
INDICATIONS :
It is indicated for temporary relief of redness and discomfort due to minor eye irritations and relief of burning and irritations due to dryness of the eye.
DOSAGE & ADMINISTRATION:
Instill one or two drops in the affected eye(s) 3 times a day.
CONTRAINDICATIONS:
It is contraindicated in patients with known history of hypersensitivity to the ingredients used in this formulation.
WARNING AND PRECAUTIONS:
To avoid contamination do not touch tip of container to any surface. Replace cap after using. If you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the conditions worsens or persists for more than 72 hours, discontinue use and consult a doctor. Keep this and all drugs out of reach of children.
SUPPLY:
ANC Eye Drops is supplied in 10ml clear poly bottles packed with printed labeled in a unit carton and, Such 25 Carton packed in a shrink sleeves.such,12 shrinks packed in a shipper.
APPASAMY ASSOCIATES (P) LTD,No.20, SBI Officer's colony,
1st Street, Arumbakkam, Chennai - 600 106, Tamil Nadu, India.
Call: ( +91 - 44 ) 30101401
E-mail : info@appasamy.com
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