ANTI-INFLAMMATORY
I-NAC
Pack : 5ml Pack
DESCRIPTION:
I-NAC Eye Drops is a sterile, topical, nonsteroidal anti-inflammatory (NSAID) prodrug for ophthalmic use. Each mL of I-NAC Eye Drops contains 1 mg of nepafenac. Nepafenac is designated chemically as 2-amino-3-benzoylbenzeneacetamide with an empirical formula of C15H14N2O2.
COMPOSITION:
Label Claim: Each ML Contains :
- Nepafenac...................0.1 % w/v
- Benzalkonium Chloride Solution IP.................0.01 %v/v (As preservative)
- Sterile Aqueous vehicle..................q.s.
PACKAGING:
Primary packing - 5ml White Poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
SHELF LIFE:
18 months from the date of manufacturing.
STORAGE:
Store at 2ºC - 25 ºC in a dark place. Do not allow to Freeze.
AVAILABILITY:
5ml of solution in White poly bottles with white caps & nozzles in properly sealed.
CLINICAL PHARMACOLOGY:
I-NAC Eye Drops contains Nepafenac (0.1%), a nonsteroidal anti-inflammatory and analgesic prodrug. After topical ocular dosing, nepafenac penetrates the cornea and is converted by ocular tissue hydrolases to amfenac, a nonsteroidal anti-inflammatory drug. Amfenac is thought to inhibit the action of prostaglandin H synthase (cyclooxygenase), an enzyme required for prostaglandin production.
INDICATIONS AND USAGE:
I-NAC Eye Drops is indicated for the treatment of pain and inflammation associated with cataract surgery.
CONTRAINDICATIONS:
I-NAC Eye Drops is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients in the formulation or to other NSAIDs.
WARNINGS AND PRECAUTIONS:
There is the potential for cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other nonsteroidal anti-inflammatory agents. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs.
DOSAGE AND ADMINISTRATION:
Shake well before use. One drop of I-NAC Eye Drops ophthalmic suspension should be applied to the affected eye(s) three-times-daily beginning 1 day prior to cataract surgery, continued on the day of surgery and through the first 2 weeks of the postoperative period.
SUPPLY:
I-NAC Eye Drops is supplied in one 5 mL Opeque Polethylene Bottle packed with printed labeled in a unit carton and, Such 25 Carton Packed in a Shrink Sleeves.Such 12 shrinks packed in a shipper.
Ketorocin-0.5
Pack : 5ml Pack
DESCRIPTION:
Ketorocin 0.5 Eye Drops is a member of the pyrrolo-pyrrole group of non-steroidal anti-inflammatory drugs ( NSAIDS ) for ophthalmic use .
COMPOSITION:
Label Claim: Each ML Contains :
• Ketorolac Tromethamine IP...............5 mg
• Benzalkonium Chloride Solution I.P..........0.1 mg (As preservative)
• Water for injection IP............q.s.
PACKAGING
Primary packing - 5ml White Poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 25ºC.Do not allow to Freeze.
AVAILABILITY :
5ml of solution in White poly bottles with white caps & nozzles in properly sealed.
CLINICAL PHARMACOLOGY:
Ketorocin 0.5 Eye Drops
a nonsteroidal anti-inflammatory drug which, when administered systemically, has demonstrated analgesic, anti-inflammatory, and anti-pyretic activity. The mechanism of its action is thought to be due to its ability to inhibit prostaglandin biosynthesis. Ketorocin 0.5 Eye Drops given systemically does not cause pupil constriction.
INDICATIONS AND USAGE:
Ketorocin 0.5 Eye Drops is indicated for the relief of ocular itching due to seasonal allergic conjunctivitis . It is also indicated for the prophylaxis and relief of post operative ocular inflammation.
CONTRAINDICATIONS
Ketorocin 0.5 Eye Drops is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients in the formulation.
WARNINGS:
There is the potential for cross-sensitivity to acetylsalicylic acid derivatives and other non-steroidal anti-inflammatory agents. Therefore, caution should be used when treating individuals who have previously exhibited sensitiveness to these drugs. With some non-steroidal anti-inflammatory drugs there exists the potential for increased bleeding time due to interference with thrombocyte aggregation . There have been reports that ocularly applied non steroida antiinflammatory drugs may cause increased bleeding of ocular tissue (including hyphemas) in conjunction with ocular surgery.
DOSAGE AND ADMINISTRATION:
The recommended dose of Ketorocin 0.5 Eye Drops is one drop four times a day in the operated eye a needed for pain and burning/ stinging for up to 4 days following corneal refractive surgery.Ketorolac tromethamine has been safely administered in conjunction with other ophthalmic medications as anti biotics, beta blockers, carbonic anhydrase inhibitors, cyclopegics and mydriatics.
SUPPLY:
Ketorocin 0.5 Eye Drops is supplied in one 5 mL Opeque Polethylene Bottle packed with printed labeled in a unit carton and, Such 25 Carton Packed in a Shrink Sleeves.Such 12 shrinks packed in a shipper.
Ketorocin-Ls
Pack : 5ml Pack
DESCRIPTION:
Ketorocin-LS Eye Drops is a member of the pyrrolo-pyrrole group of non-steroidal anti-inflammatory drugs ( NSAIDS ) for ophthalmic use.
COMPOSITION:
Label Claim: Each ML Contains :
• Ketorolac Tromethamine IP...............4 mg
• Stabilized Oxychloro complex..........0.05 mg (As preservative)
• Water for injections IP............ .q.s.
PACKAGING
Primary packing -5ml White Poly bottles White caps &Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box..
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 25ºC.Do not allow to Freeze.
AVAILABILITY :
5ml of solution in White poly bottles with white caps & nozzles in properly sealed.
CLINICAL PHARMACOLOGY:
Mechanism of Action:
Ketorocin-LS Eye Drops is a nonsteroidal anti-inflammatory drug which, when administered systemically, has demonstrated analgesic, anti-inflammatory, and anti-pyretic activity. The mechanism of its action is thought to be due to its ability to inhibit prostaglandin biosynthesis. Ketorolac tromethamine given systemically does not cause pupil constriction.
Pharmacokinetics:
One drop (0.05 mL) of 0.5% Ketorocin-LS Eye Drops was instilled into one eye and one drop of vehicle into the other eye TID in 26 normal subjects. Only 5 of 26 subjects had a detectable amount of ketorolac in their plasma (range 10.7 to 22 5 ng/mL) at day 10 during topical ocular treatment.
Clinical Studies:
In two double-masked, multi-centered, parallel-group studies, 313 patients who had undergone photorefractive keratectomy received Ketorocin-LS Eye Drops or its vehicle QID for up to 4 days. Significant differences favored Ketorocin-LS Eye Drops for the reduction of ocular pain and burning/stinging following photorefractive keratectomy surgery.
Results from clinical studies indicate that ketorolac tromethamine has no significant effect upon intraocular pressure.
Ketorocin-LS Eye Drops is a nonsteroidal anti-inflammatory drug which, when administered systemically, has demonstrated analgesic, anti-inflammatory, and anti-pyretic activity. The mechanism of its action is thought to be due to its ability to inhibit prostaglandin biosynthesis. Ketorolac tromethamine given systemically does not cause pupil constriction.
INDICATIONS AND USAGE:
Ketorocin-LS Eye Drops is indicated for the relief of ocular itching due to seasonal allergic conjunctivitis. It is also indicated for the prophylaxis and relief of post operative ocular inflammation.
CONTRAINDICATIONS
Ketorocin-LS Eye Drops is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients in the formulations..
WARNINGS:
There is the potential for cross-sensitivity to acetylsalicylic acid derivatives and other non-steroidal anti-inflammatory agents. Therefore, caution should be used when treating individuals who have previously exhibited sensitiveness to these drugs. With some non-steroidal anti-inflammatory drugs there exists the potential for increased bleeding time due to interference with thrombocyte aggregation . There have been reports that ocularly applied non steroidal antiinflammatory drugs may cause increased bleeding of ocular tissue (including hyphemas) in conjunction with ocular surgery.
DOSAGE AND ADMINISTRATION:
The recommended dose of Ketorocin-LS Eye Drops is one drop four times a day . Ketorocin-LS Eye Drops has been safely administered in conjunction with other ophthalmic medications as anti biotics, beta blockers, carbonic anhydrase inhibitors, cyclopegics and mydriatics.
SUPPLY:
Ketorocin-LS Eye Drops is supplied in one Opeque Polethylene Bottle packed with printed labeled in a unit carton and, Such 25 Carton Packed in a Shrink Sleeves.Such 12 shrinks packed in a shipper.
PREDS
Pack : 5ml & 10ml Pack
DESCRIPTION:
PREDS-Ophthalmic Suspension (Prednisolone acetate Ophthalmic Suspension USP) is synthetic analog of glucocorticoide hydrocortisone (cortisol), has an anti-inflammatory action for ophthalmic use.
COMPOSITION:
Label Claim: Each ML Contains :
• Prednisolone Acetate IP ........................10 mg.
• Benzalkonium Chloride Solution IP ......0.2 mg (As preservative)
• Sterile aqueous vehicle ........................q.s.
PACKAGING
Primary packing - 5mL & 10mL Clear Poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 25ºC.Do not allow to Freeze.
AVAILABILITY:
5mL & 10mL of solution in Clear poly bottles with white caps & nozzles in properly sealed.
CLINICAL PHARMACOLOGY:
Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. There is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.Corticosteroids are capable of producing a rise in intraocular pressure.
INDICATIONS AND USAGE:
Steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe such as allergic conjunctivitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, selected infective conjunctivitides, when the inherent hazard of steroid use is accepted to obtain an advisable diminution in edema and inflammation; corneal injury from chemical, radiation, or thermal burns, or penetration of foreign bodies.
CONTRAINDICATIONS:
PREDS-Ophthalmic Suspension is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.
Prednisolone Acetate Ophthalmic Suspension USP, 1% is also contraindicated in individuals with known or suspected hypersensitivity to any of the ingredients of this preparation and to other corticosteroids.
WARNINGS:
FOR TOPICAL OPHTHALMIC USE ONLY. Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision, and in posterior subcapsular cataract formation. Prolonged use may also suppress the host immune response and thus increase the hazard of secondary ocular infections.Various ocular diseases and long-term use of topical corticosteroids have been known to cause corneal and scleral thinning. Use of topical corticosteroids in the presence of thin corneal or scleral tissue may lead to perforation. Acute purulent infections of the eye may be masked or activity enhanced by the presence of corticosteroid medication. If this product is used for 10 days or longer, intraocular pressure should be routinely monitored even though it may be difficult in children and uncooperative patients. Steroids should be used with caution in the presence of glaucoma. Intraocular pressure should be checked frequently.The use of steroids after cataract surgery may delay healing and increase the incidence of bleb formation. Use of ocular steroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex). Employment of a corticosteroid medication in the treatment of patients with a history of herpes simplex requires great caution; frequent slit lamp microscopy is recommended. Corticosteroids are not effective in mustard gas keratitis and Sjogren's keratoconjunctivitis.
DOSAGE AND ADMINISTRATION:
SHAKE WELL BEFORE USING. Two drops topically in the eye(s) four times daily. In cases of bacterial infections, concomitant use of anti-infective agents is mandatory. Care should be taken not to discontinue therapy prematurely. If signs and symptoms fail to improve after two days, the patient should be
re-evaluated The dosing of PREDS-Ophthalmic Suspension 1% may be reduced, but care should be taken not to discontinue therapy prematurely. In chronic conditions, withdrawal of treatment should be carried out by gradually decreasing the frequency of applications.
SUPPLY:
PREDS-Ophthalmic Suspension is supplied in one Clear Polethylene Bottle packed with printed labelled & cartons And Such 25 Carton Packed in a Shrink Sleeves & corrugated box.
Flurocot
Pack : 5ml Pack
DESCRIPTION:
Flurocot Eye Drops is an anti inflammatory agent inhibits the edema,fibrin deposition,capillary dilation and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen and scar formation.
COMPOSITION:
Label Claim: Each ML Contains :
• Fluorometholone Acetate USP.........1 mg
• Benzalkonium Chloride Solution IP .......0.1 mg (As preservative)
• Sterile aqueous buffered vehicle............q.s.
PACKAGING
Primary packing - 5ml Clear Poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 25ºC.Do not allow to Freeze.
AVAILABILITY:
5ml of solution in Clear poly bottles with white caps & nozzles in properly sealed.
INDICATIONS AND USAGE:
Flurocot Eye Drops is indicated for use in the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the eye.
Flurocot Eye Drops is used to treat certain eye conditions due to inflammation or injury. Fluorometholone works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.
CONTRAINDICATIONS:
Contraindicated in acute superficial herpes simplex keratitis, vaccinia, varicella, and most other viral diseases of cornea and conjunctiva; tuberculosis; fungal diseases; acute purulent untreated infections, which like other diseases caused by microorganisms, may be masked or enhanced by the presence of the steroid; and in those persons who have known hypersensitivity to any component of this preparation.
WARNINGS AND PRECAUTIONS:
Use in the treatment of herpes simplex infection requires great caution. Prolonged use may result in glaucoma, damage to the optic nerve, defect in visual acuity and visual field, cataract formation and/or may aid in the establishment of secondary ocular infections from pathogens due to suppression of host response. Acute purulent infections of the eye may be masked or exacerbated by presence of steroid medication. In those diseases causing thinning of the cornea or sclera, perforation has been known to occur with chronic use of topical steroids. It is advisable that the intraocular pressure be checked frequently.
DOSAGE AND ADMINISTRATION:
Shake Well Before Using. One to two drops instilled into the conjunctival sac(s) four times daily. During the initial 24 to 48 hours the dosage may be safely increased to two drops every two hours. If no improvement after two weeks, consult physician. Care should be taken not to discontinue therapy prematurely.
SUPPLY:
Flurocot Eye Drops is supplied in 5 ml clear poly bottles packed with printed labeled in a unit carton and, Such 25 Carton packed in a shrink sleeves.such,12 shrinks packed in a shipper.
Aflur
Pack : 5ml Pack
DESCRIPTION:
Aflur- Eye Drops (Flurbiprofen eye drops) are used to keep the pupils of the eye from getting smaller (miosis) during an eye surgery. This medicine is a topical nonsteroidal anti-inflammatory drug (NSAID).
COMPOSITION:
Label Claim: Each ML Contains :
• Flurbiprofen Sodium IP........ 0.3 mg
• Thimerosal IP............0.05 mg
• Aqueous Buffered Vehicle........q.s.
PACKAGING:
Primary packing - 5ml White Poly bottles White caps & Nozzles.
Secondary Packing - Labels, Cartons, Shrink Pack & Shipper box.
AVAILABILITY:
5ml of solution in White poly bottles with white caps & nozzles in properly sealed.
SHELF LIFE:
24 months from the date of manufacturing.
STORAGE:
Keep in a cool & dark place. Below 25ºC.Do not allow to Freeze.
CLINICAL PHARMACOLOGY:
Flurbiprofen sodium is one of a series of phenylalkanoic acids that have shown analgesic, antipyretic, and anti-inflammatory activity in animal inflammatory diseases. Its mechanism of action is believed to be through inhibition of the cyclo-oxygenase enzyme that is essential in the biosynthesis of prostaglandins.Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed on animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilatation, increased vascular permeability, leukocytosis, and increased intraocular pressure.Prostaglandins also appear to play a role in the miotic response produced during ocular surgery by constricting the iris sphincter independently of cholinergic mechanisms. In clinical studies, Aflur- Eye Drops has been shown to inhibit the miosis induced during the course of cataract surgery.Results from clinical studies indicate that flurbiprofen sodium has no significant effect upon intraocular pressure.
INDICATIONS AND USAGE:
Aflur- Eye Drops is is indicated for the inhibition of intraoperative miosis.
CONTRAINDICATIONS:
Aflur-Eye Drops is contraindicated in individuals who are hypersensitive to any components of the medication.
WARNINGS:
With some nonsteroidal anti-inflammatory drugs, there exists the potential for increased bleeding time due to interference with thrombocyte aggregation. There have been reports that Aflur- Eye Drops may cause increased bleeding of ocular tissues (including hyphemas) in conjunction with ocular surgery.There is the potential for cross-sensitivity to acetylsalicylic acid and other nonsteroidal anti-inflammatory drugs. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs.
DOSAGE AND ADMINISTRATION:
A total of four (4) drops of Aflur- Eye Drops should be administered by instilling one (1) drop approximately every 1/2 hour beginning 2 hours before surgery.
SUPPLY:
Aflur- Eye Drops is supplied in one White polethylene Bottle packed with printed labelled & cartons And Such 25 Carton Packed in a Shrink Sleeves & corrugated box.